Bottega Organica Lavender Nourishing Face Oil Highly Recommended by the Gorgeous Women of Whom You Know!

Whose face doesn’t desperately need moisture and nourishment, especially during cold, dry weather? I’m sure there are some of you out there, but for the rest of us mere mortals, there’s Bottega Organica’s Lavender Nourishing face oil to make our complexions look and feel super-human. The list of natural skin-care products is growing, but Bottega Organica has set the bar extremely high with this face oil. Containing a host of natural ingredients that, in addition to their skin-nourishing qualities, smell divine! We expect the lavender of course, since it’s in the name, but it also contains olive oil, sage, lilac and grape leaf extract. Yet somehow this wonderful blend of ingredients smells slightly of peppermint! Most of the ingredients are certified organic or harvested directly by Bottega Organica. This is definitely an oil, so be prepared for that, but once you give this wonderful a chance to absorb, your skin will feel nourished like never before. 

Bottega Organica Lavender Nourishing face oil is perfect preparation for blissful slumber and beautiful skin upon awakening. It is also an instant olfactory pleasure! The scent reminded me of entering my favorite spa for some relaxing aromatherapy. This oil has a rich, moisturizing texture yet it is fully absorbed without any oily residue. You can see the high quality of its ingredients in its fresh from the farm appearance, reminding me of olive oil I bought in the vineyards of Italy! The olive oil is obtained through the same day cold-pressing of handpicked organically-grown olives and trust me, this makes a difference! My skin felt rejuvenated after just one week of use, especially as I combined it with an application of Bottega Organica’s Autumn Sage Ultra Concentrated Face Serum first. I highly recommend this winning combination to make your skin feel and look younger. Who would not want these results?

Is there anything more calming than the scent of lavender? One sniff of anything lavender-scented and I can immediately feel my shoulders go down, my muscles relax, and my mind stop rushing. Well, thanks to Bottega Organica and their Lavender Nourishing Face Oil, I now start my days with that beautiful scent, and work wonders on my skin at the same time! Bottega Organica is dedicated to combining the very best anti-aging research from world-renowned geneticist Dr. Andrea Alimonti with all natural, anti-aging plant extracts - providing a fantastic line of anti-aging skincare without the harsh chemicals that can often be associated with such products. Their Lavender Nourishing Face Oil is made with extracts derived from rosemary, lemon balm, grape leaves, French lilac, and golden and prawn sage, all of which have anti-aging properties. The lavender not only provides relaxing qualities for the skin, but it also serves as an antiseptic. I've been using this oil for a few weeks now, and am completely addicted! My skin has never looked better, and the scent is absolutely heavenly. Highly recommended by this panelist!

I want my face to look its best: clean, fresh and youthful but if you are like me then you never really know where the products you use are coming from. That is why I really like Lavender Nourishing Face Oil from Bottega Organica. This fantastic brand takes the farm to table concept and shakes it up to farm to face. Yes, that's right all ingredients come from their farm in Liguria, Italy. These pure and fine extracts are grown wild without the use of fertilize or pesticides. This lovely face oil smells amazing and feels so soft on your skin. It can be used morning and night after cleansing. It contains extracts from rosemary, sage, grape leaves and French lilac, leaving your skin glowing and healthy.

Apply after cleansing, say the instructions, but we are so mesmerized by the Bottega Organica line, that we apply after using their serum, day and night. All the way to the décolleté, for a softer face, neck and beyond , these herbs will defend and replenish your skin cells. Bottega Organica has developed a line of skincare developed by science, and married to nature in it’s purest form. Their steam extracted plant essences are suspended in olive oil, glycerin, and water bases to provide a natural and non-invasive method of delivery to your skin. Once you begin to read about this skincare line, you will become even more intrigued by the properties of the herbs selected. Based on molecular genetics, the science behind the company concentrates on inhibiting cellular senescence. It’s a big word that simply means “aging”, and one of the things we do battle with on a daily basis. The smoothness of your skin will prove the product, and allow your face to develop it’s glow once again. It’s medicine for your skin, in a luxury wrapper.

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While studying anti-tumor therapies, molecular geneticist Dr. Andrea Alimonti developed a screening method to detect the anti-aging properties of natural ingredients. 

Dr. Alimonti screened thousands of natural substances for anti-aging properties and identified a handful of “Natural Inhibitors of Senescence” (NIS): natural substances with the potential of slowing the aging of human cells. Tested on human cell lines, these substances prolong cellular life and slow aging by inhibiting different types of cellular senescence and rejuvenate cells by regulating genes. The most active NIS is one of the over 900 species of sage: salvia haenkei. 

In 2011, Dr. Alimonti and a group of doctors founded Bottega Organica™, to create a revolutionary line of 100% organic, all-natural skincare products with proven anti-aging activity. 

Under the direction of Dr. Alimonti, optimal concentrations of powerful anti-aging medicinal plants (NIS) are blended with pure Ligurian olive oil, rich in anti-oxidants and natural vitamins. The same NIS, including powerful concentrates of salvia haenkei, are blended into proprietary formulas of non-oil based, hydro-soluble, vegan serums. These two natural vehicles, extra-virgin Ligurian olive oil and non-oil based serums, effectively deliver NIS activity (natural rejuvenating molecules) to the skin. 

BOTTEGA ORGANICA MISSION STATEMENT: DESIGNED BY SCIENCE / MADE FROM NATURE 

In keeping with a strong commitment to natural ingredients Bottega Organica tends to several hectares of fertile, uncontaminated land in the coastal regions of Liguria, Italy, where herbs and fruits with anti-aging properties grow wild and are harvested naturally, without pesticides and chemical fertilizers. 

At Bottega Organica we use the purest and finest organic ingredients harvested from our own farm. Olives are cold pressed to create the base for our rejuvenating oils and we use steam extraction to obtain essential oils and flower waters from wild leaves such as lavender, sage and chamomile. Our research and development teams then creates unique anti-aging formulations which contain optimal concentrations of Natural Inhibitors of Senescence (NIS) blended into natural oils or rejuvenating organic and vegan serums for optimal delivery to the skin. 

The doctors leading the Bottega Organica team believe that synthetic skin products carry health risks, are not planet friendly and do not offer the many advantages of fully botanical products, naturally rich in molecules with anti-aging activity. 

While many skincare companies claim to offer natural products, the reality is that the milky base of creams and lotions contains plastic or, at best, an emulsion with synthetic ingredients and preservatives. Day after day, those preservatives and synthetic emulsifiers penetrate the skin, reach the bloodstream and spread throughout the body with potentially harmful effects. This is why Bottega Organica does not produce creams or lotions and relies instead on the simplicity and safety of pure olive oil, organic and vegan serums and spring water. 

· All Bottega Organica products contain a blend of NIS, scientifically proven by Dr. Alimonti’s proprietary screening method to prolong the youthful appearance of human skin. 

· Our products are free from synthetic fragrances, dyes, flavors or preservatives. Our products are 100% vegetarian and organic and we use no petroleum derivatives and no synthetic ingredients. 

· We choose to limit the number of ingredients in our products, favoring science, effectiveness and natural purity. All listed ingredients are harvested in our Bottega Organica farm, or are certified organic from known growers or are natural components of organic essential oils. Always natural, never synthetic. 

· Our products are designed to create customizable regimens in order to increase their efficacy. 

· All Bottega Organica products are thoroughly tested under strict safety parameters, with no animal testing. 

· All packaging is recyclable and made from 100% recycled paper with vegetable printing. Our store at 117 Christopher street in NYC, NY was built with 100% reclaimed wood, recycled and recyclable materials and vegetable based paint. 

ABOUT DR. ALIMONTI 

For the past decade, Dr. Alimonti has been recognized for his research, publications and lectures in the area of molecular oncology. He worked for several years at Memorial Sloan Kettering Cancer Center in NY and at Harvard Medical School in Boston. He currently serves as Director of Molecular Oncology at the Institute of Oncology Research in Bellinzona, Switzerland and is PD Professor in Oncology at the University of Lausanne in Switzerland. Dr. Alimonti published several pivotal papers about the mechanisms that regulate senescence*. His discoveries will lead innovation in anti-aging strategies and skincare for years to come. 

Throughout his personal life and career, Dr. Alimonti had a strong commitment to a holistic approach to medicine and his partnership with Bottega Organica gave him the opportunity to use scientific knowledge to uncover the anti-aging powers of nature. 

*CELLULAR SENESCENCE & AGING 

Our cells are programmed by a “biological clock” that only allows a limited number of cell divisions. Cellular Senescence is the phenomenon where cells lose their ability to divide or replicate after about 50 cell divisions (also known as "replicative senescence" or the "Hayflick phenomenon"). Senescence cells become flat and stain positive (blue) for a typical marker of senescence known as SA-b-Galactosidase staining (Fig.1)1. Factors that can accelerate senescence include: radiation (photoaging), free radicals, metabolic stresses and oncogene (tumor causing) activation. Though they no longer replicate, senescent cells remain metabolically active and studies have shown that they can secrete substances that can cause aging in normal tissues2. Further studies have demonstrated that removing senescent cells provides resistance to age related diseases and decelerates tissue dysfunction3. This suggests that intervention that decreases the number of senescence cells in the skin or other tissues are effective in limiting the effects of aging. 

CAUSES OF ACCELLERATED SENESCENCE 

Radiation (photoaging) 

Photoaging is aging of the skin (especially the skin of the face, ears, neck and hands) caused by over exposure to UVA and UVB rays. UVB rays can cause wrinkling by penetrating through the epidermal layer, increasing damage to elastin and collagen. Additionally, UVB rays are responsible for the formation of freckles, dark spots and precancerous lesions or skin cancer. UVA rays penetrate deeper into the skin than UVB rays reaching the dermal layer and compromising the structural support of the skin. These rays can decrease the synthesis of collagen and elastin and can also lead to enlarged and damaged blood vessels often seen on the nose and cheeks. 

Free radicals 

Free radicals are highly unstable and chemically reactive molecules generated by exposure to UV rays, pollution, infrared radiation and lifestyle habits such as alcohol abuse and smoking. Inside the skin, free radicals damage cells, their DNA, and other vital cellular components. Over time, free radical damage leads to visible signs of accelerated skin aging, including fine lines, wrinkles, laxity, discoloration, and even skin cancer. 

Metabolic stress 

Metabolic stress such as high-calorie dietary intake, especially from highly processed foods of poor nutritional quality - empty calories - can increase the production of reactive oxygen species (ROS), which are responsible for DNA damage. Studies have linked calorie restriction and sound dietary habits to reduced ROS and slower aging. 

Oncogene activation 

Oncogene mutation or over-expression and loss of tumor suppressor genes can trigger senescence in human cells. 

“NATURAL INHIBITORS OF SENESCENSE” (NIS): HOW DO THEY WORK? 

Natural inhibitors of senescence (NIS) are natural substances discovered by Dr. Alimonti and formulated according to patented technology (5) that have the potential to prevent human senescence. NIS can block different types of senescence, including the one known as replicative senescence, by slowing down the biological clock that defines the limited number of cell divisions. A decreased accumulation of senescence cells in tissue cultures has been shown to decrease the secretion of factors known to accelerate aging in normal cells. Figure 2 shows the effect of HAEN, one of the most powerful NIS identified by Dr. Alimonti, in blocking senescence. HAEN was originally discovered in a screening platform developed by Dr. Alimonti for the identification of pro-senescence compounds in Pten null cells with hyperactive PI3K/mTor pathway. These cells undergo a particular type of accelerated senescence known as PICS4. In contrasts to compounds that enhances senescence, HAEN was a strong inhibitor of senescence driven by Pten loss and was therefore chosen for its anti-aging activity. Cells treated with HAEN blended with natural oils and other anti-aging medicinal plants do not accumulate SA-b-Galattosidase (Fig. 2 right panel), which is a recognized marker of senescence. These cells remain younger for a longer period of time compared to control cells not exposed to NIS. Experiments done on human dermal fibroblasts, using passaging cells in cultures in the presence or absence of HAEN, demonstrated that untreated fibroblasts stop growing between passages 28-30. Cells, treated with HAEN however, continue to grow and duplicate. The number of senescent cells in culture also decreased by 50% when compared to control cells. These findings suggest that HAEN is an effective NIS that can slow down aging by counteracting replicative senescence. 

Of note, treatment of cells with high concentration of HAEN for up to 3 months showed no sign of toxicity on human cells. 

NIS are also effective in antagonizing accelerated senescence caused by UV irradiation. In these experiments, HAEN can block photoaging in human fibroblasts exposed to UVB radiations. The effect is already evident 24h after the irradiation of the cells as shown by the decreased percentage of SA-b-Galactosidase in cells treated with HAEN (Fig. 3). NIS can also change the gene expression profile of dermal fibroblasts (Fig.4). HAEN decreases the gene expression levels of IL1a in a three-dimensional model of reconstructed human skin. IL1 is the essential chemokine linked to skin inflammation. Moreover IL1 is essential in regulating paracrine senescence and experimental evidence demonstrates that cells lacking IL1 cannot enter in senescence when exposed to UV irradiation. Reduction of IL1 in the human skin protects it from inflammation and from the accumulation of free radicals. In conclusion, Dr. Alimonti’s proprietary formulas rich in NIS potentially counteract all contributors to accelerated senescence. 

References 

1. Nardella C, Clohessy JG, Alimonti A, Panodlfi PP. Pro-senescence therapy for cancer treatment. Nat Rev Cancer. 2011 Jun 24;11(7):503-11 

2. Acosta JC, Banito A, et al. Complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013 Aug;15(8):978-90 

3. Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600. 

4. Alimonti A., Nardella C, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010 Mar; 120 (3): 681-93. 

5. Patent number: IT EP US BI4533R RM2013A000063 Inventor: Dr. Andrea Alimonti.